Abstract
Circulating tumor cells in gastric cancer
Highlights
Gastric cancer is the sixth most common cancer and the third leading cause of cancer death worldwide[1]
It is expected that the research of circulating tumor cells (CTCs) elucidates the biological mechanisms of cancer metastasis and leads to better understanding of tumor heterogeneity
We review the latest progress of CTCs in gastric cancer
Summary
Gastric cancer is the sixth most common cancer and the third leading cause of cancer death worldwide[1]. Cancer metastasis and recurrence have been conventionally diagnosed by imaging test or serum tumor marker; these modalities cannot provide a precise and timely assessment of the process of metastasis and recurrence. This process has been interpreted as involving the circulating tumor cells (CTCs), which are infiltrated into the bloodstream. All steps are absolutely integral to the establishment of metastasis In these processes, CTCs exhibit phenotypic diversity, such as epithelial mesenchymal transition (EMT) phenotype, and cancer stem cell (CSC) phenotype[9], which facilitates metastasis. A recent study revealed that CD44-positive CTCs decreased after surgery or chemotherapy; they may be a predictive marker of treatment response in gastric cancer[16]
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