Circulating Sestrin Levels Are Increased in Hypertension Patients.

Cao Fang,Tao Zeng,Yingzhong Lin,Hongtao Liu,Zicong Yang,Lei Shi,Ying Shi,Ling Liu

doi:10.1155/2020/3787295

Abstract

Background Sestrins (Sesns), a group of oxidative stress-related proteins, have been reported to be involved in various cardiovascular diseases, including aortic dissection and chronic heart failure. This study is aimed at investigating the level of circulating Sesn1, Sesn2, and Sesn3 in hypertension patients. Methods Plasma levels of Sesn1, Sesn2, and Sesn3 in 400 hypertensive patients and 100 normotensive subjects were detected using enzyme-linked immunosorbent assay (ELISA) kits. The hypertension patients were divided into groups with grade I (n = 140), grade II (n = 180), and grade III (n = 80) hypertension. Results Compared with the normotensive subjects, Sesn1, Sesn2, and Sesn3 levels were increased in patients with hypertension, with a gradual increase between the groups with grade I, grade II, and grade III hypertension. Elevated Sesn1, Sesn2, and Sesn3 levels were positively correlated with both the systolic blood pressure (SBP) and diastolic blood pressure (DBP). Moreover, Sesn1, Sesn2, and Sesn3 levels were elevated in patients with dipper hypertension and further increased in patients with nondipper hypertension. In addition, smokers, as well as patients with higher levels of angiotensin II (Ang II) and carotid atherosclerotic plaque (CAP), exhibited increased Sesn1, Sesn2, and Sesn3 levels when compared with patients without these clinical characteristics. Furthermore, plasma levels of Sesn1, Sesn2, and Sesn3 were negatively correlated with the presence of CAP. Conclusions Circulating Sesn levels are increased in patients with hypertension and may be a target for the prevention and treatment of clinical hypertension.

Highlights

Hypertension is the most common risk factor of cardiovascular disease, leading to significantly higher morbidity and mortality than other risk factors
The results of our study revealed that Sesn1, Sesn2, and Sesn3 levels were significantly increased in hypertension patients when compared with the normotensive subjects
A further analysis showed a positive correlation between plasma Sesn levels and blood pressure values, including systolic blood pressure (SBP) and diastolic blood pressure (DBP)

Summary

Introduction

Hypertension is the most common risk factor of cardiovascular disease, leading to significantly higher morbidity and mortality than other risk factors. A number of studies have confirmed that Sesns are involved in the development and progression of various diseases, by regulating oxidative stress. Sestrins (Sesns), a group of oxidative stress-related proteins, have been reported to be involved in various cardiovascular diseases, including aortic dissection and chronic heart failure. This study is aimed at investigating the level of circulating Sesn, Sesn, and Sesn in hypertension patients. Compared with the normotensive subjects, Sesn, Sesn, and Sesn levels were increased in patients with hypertension, with a gradual increase between the groups with grade I, grade II, and grade III hypertension. Circulating Sesn levels are increased in patients with hypertension and may be a target for the prevention and treatment of clinical hypertension

Objectives

Methods

Conclusion