Circulating S100A12 Levels Are Associated with Progression of Abdominal Aortic Calcification in Hemodialysis Patients.

Byoung Ho Choi,Eul Sik Jung,Wookyung Chung,Han Ro,Jae Hyun Chang,Ae Jin Kim,Ji Yong Jung,Hyun Hee Lee,Elena Aikawa

doi:10.1371/journal.pone.0150145

Byoung Ho Choi, Eul Sik Jung + Show 7 more

Open Access

https://doi.org/10.1371/journal.pone.0150145

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Journal: PloS one	Publication Date: Feb 25, 2016
Citations: 10	License type: CC BY 4.0

Affiliation: Gachon University Gil Medical Center, Gachon University

Abstract

Vascular calcification is an important factor associated with mortality in dialysis patients. Recently, soluble receptor for advanced glycation end product (sRAGE) and extracellular RAGE binding protein S100A12 (EN-RAGE) have been reported to be involved in the process of vascular calcification. Therefore, we investigated whether sRAGE and S100A12 are useful indicators of progression of abdominal aortic calcification in hemodialysis (HD) patients. We analyzed annual changes in vascular calcification score (VCS) for up to 4 years, compared to clinical and biological parameters in 149 HD patients. VCS was assessed annually using plain X-ray images of the lateral lumbar spine. The progression group was defined as patients with an increase in VCS more than 1 point each year on average during the observation period. Time-averaged concentrations were also evaluated to examine the association between biological parameters and changes in VCS. The patients had a mean age of 58.59 ± 12.93 years; 53.7% were male, and 45% were diabetic. The VCS increased in 55 patients; the mean increase was 1.60 ± 2.91 points. In a stepwise multivariate logistic analysis, we found that higher levels of S100A12 were significantly associated with progression of VCS (odds ratio [OR], 2.622; 95% confidence interval [CI], 1.371–5.016; P = 0.004). The relationship between sRAGE and VCS was not statistically significant (OR, 0.644; 95% CI, 0.302–1.374; P = 0.255). Our findings suggest that serum levels of S100A12 are associated with progression of abdominal aortic calcification in HD patients, independent of sRAGE level.

Highlights

Cardiovascular mortality of patients undergoing dialysis is at least 10-fold higher than that in the general population [1]
Our findings showed that S100 calcium-binding protein A12 (S100A12) is a risk factor for progression of abdominal aortic calcification
After adjusting for confounding factors, S100A12 remained significantly related to changes in vascular calcification score (VCS) in HD patients

Summary

Introduction

Cardiovascular mortality of patients undergoing dialysis is at least 10-fold higher than that in the general population [1]. Ischemic heart disease, such as acute myocardial infarction, is life threatening. Cardiovascular disease (CVD) is the most important factor that increases the mortality rate of dialysis patients [2]. A previous cross-sectional study by our group reported that sRAGE has an inverse correlation with vascular calcification in HD patients [11]. Most cross-sectional studies to date have investigated the correlation between vascular calcification and S100A12 and sRAGE, and only few studies have evaluated the progression of vascular calcification in other groups of patients. We performed a longitudinal 4-year follow-up observational study and investigated the associations between VCS and S100A12, sRAGE, and other factors at baseline and over time

Study design and setting

Results

Discussion