Circulating PGRN Levels Are Increased but Not Associated with Insulin Sensitivity or β-Cell Function in Chinese Obese Children.

Fengyun Wang,Jie Shen,Ting Chen,Haitao Lv,Xuan Li,Zhenyu Chu,Ling Sun,Linqi Chen,Miao Hou

doi:10.1155/2018/3729402

Abstract

Progranulin (PGRN), a novel peptide that has recently emerged as an important regulatory adipokine, is relevant to energy homeostasis and obesity in animals and adult humans. Little is known about its roles in children. The aim of the current study was to determine the potential role of PGRN and explore its relationship to various obesity-related markers in obese children. This was a cross-sectional study composed of 77 children (43 obese and 34 healthy, age 8.68 ± 0.28 and 8.46 ± 0.45 years, resp.). The PGRN levels were significantly higher in obese children (102.44 ± 4.18 ng/mL) comparing to controls (69.32 ± 5.49 ng/mL) (P < 0.05). Moreover, the PGRN levels were positively correlated with triglyceride (TG), total cholesterol (TC), IL-6, systolic blood pressure (SBP), and diastolic blood pressure (DBP) in obese children after adjusted for BMI and age. However, there was no correlation of serum PGRN levels with OGTT-derived dynamic parameters, HOMA-IR, or HOMA-β in obese children. The results suggest that serum PGRN levels are significantly higher in obese children in China and correlate significantly with obesity-related markers. Increased PGRN levels may be involved in the pathological mechanism of childhood obesity.

Highlights

Childhood obesity has become a global public health issue
Those in the obesity group had significantly higher BMI, systolic blood pressure (SBP), diastolic blood pressure (DBP), TG, low-density lipoprotein cholesterol (LDL)-C, insulin, HbAC1, GPT, homeostasis model assessment for insulin resistance (HOMA-IR), homeostasis model assessment for β-cell function (HOMA-β), insulinogenic index, C-peptide index, hsCRP, IL-6, and TNF-α levels than the control group, whereas high-density lipoprotein cholesterol (HDL)-C levels were lower in obesity group compared with control group
The present study analyzed the data of obese Chinese children, aiming to investigate whether correlations could be found between PGRN levels and obesity in this population

Summary

Introduction

The prevalence of obesity has tripled in the last three decades. Childhood obesity is associated with a number of adverse health consequences including type 2 diabetes (T2DM), dyslipidemia, and hypertension, all of which will lead to premature cardiovascular diseases [2, 3]. In addition to energy storage, has been found to have a variety of endocrine functions. It can secrete all kinds of adipokines [4, 5], including leptin, adiponectin, and resistin, all of which play important roles in metabolism and energy homeostasis. PGRN has emerged as an important regulatory adipokine of glucose metabolism and insulin sensitivity [8, 9]. PGRN affects insulin signaling and suppresses insulin-stimulated glucose uptake

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Conclusion