Abstract
Recent study showed periostin play a pivotal role in abnormal liver triglyceride (TG) accumulation and in the development of obesity-related liver fat accumulation. However, little is known regarding whether periostin plays a key role in the heightened prevalence of NAFLD and other metabolic phenotypes among large-scale populations. A cross-sectional sample of 8850 subjects aged 40 yr or older from China were evaluated in this study. Serum periostin was measured by ELISA methods. The diagnosis of NAFLD by liver ultrasonic examination. Among overweight and obese subjects, NAFLD subjects had higher serum periostin levels than those without NAFLD (126.75 ng/ml vs. 75.96 ng/ml, p < 0.001). Periostin was associated with a higher risk for NAFLD (OR 1.75 for each SD increase in periostin, 95% CI 1.04–3.37, p < 0.001) among overweight and obese subjects after confounder adjustment. Furthermore, periostin levels among overweight and obese subjects were correlated with aspartate aminotransferase (r = 0.102, p = 0.004), alanine aminotransferase (r = 0.108, p = 0.003), waist circumference (r = 0.111, p = 0.002), homeostasis model assessment index-insulin resistance (r = 0.154, p < 0.001) and fasting plasma insulin (r = 0.098, p = 0.006), TG (r = 0.117, p = 0.001). Elevated circulating periostin level was associated with an increased risk of having NAFLD and insulin resistance among overweight and obese individuals.
Highlights
IntroductionPrevious studies have confirmed that several hepatokines which secreted by liver could involved in regulate systemic and liver lipid and glucose metabolism[12,13,14]
Among overweight and obese subjects, NAFLD patients showed circulating periostin value higher than their counterpart non-NAFLD subjects (126.75 ± 21.37 ng/ml vs. 75.96 ± 17.92 ng/ml, p < 0.001), whereas lean subjects did not show any significant difference in periostin levels based on NAFLD (72.65 ± 18.15 ng/ml vs. 58.59 ± 16.36 ng/ml, p = 0.259)
We demonstrated that higher periostin levels were significantly associated with increased risk of having NAFLD among overweight and obese subjects
Summary
Previous studies have confirmed that several hepatokines which secreted by liver could involved in regulate systemic and liver lipid and glucose metabolism[12,13,14]. Taken together, these findings indicated that periostin could serve as a novel hepatokine to regulate hepatic fat metabolism. Postn−/− mice showed impaired pancreatic regeneration in the islet β-cell[15]. The purpose of this study is to examine the association between serum periostin levels and NAFLD as well as other metabolic phenotypes in Chinese people
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