Circulating pentraxin 3 is positively associated with chronic hyperglycemia but negatively associated with plasma aldosterone concentration.

Yuichi Takashi,Tetsuo Nishikawa,Minae Koga,Jun Saito,Masao Omura,Yoko Matsuzawa,Giuseppe Danilo Norata

doi:10.1371/journal.pone.0196526

Abstract

Pentraxin 3 (PTX3) is reported to be a vascular inflammation marker providing prognostic information of vasculopathy. Until today, however, the effect of aldosterone or oxidative stress on the regulation of PTX3 is unknown. In present study, we investigated to find regulative factors, especially aldosterone and oxidative stress, on PTX3. Serum PTX3 levels were measured in 75 patients (45 male and 30 women, aged 55.1±13.4 year-old (mean±SD)) with various endocrine disorders including 47 with diabetes, 24 with primary aldosteronism (PA). All participants were free from cardio vascular diseases and diabetic retinopathy. Serum PTX3 level was significantly lower in patients with PA than without PA and was significantly higher in patients with diabetes than without diabetes. PTX3 was significantly correlated with glycated hemoglobin (HbA1c), urinary albumin excretion (UAE) and plasma aldosterone concentration (PAC) (r = 0.431, P<0.001; r = 0.313, P = 0.009; r = -0.375, P = 0.004). A stepwise multiple regression analysis chose HbA1c and UAE as independent determinants of PTX3 (β = 0.282, P<0.001; β = 0.783, P<0.001). On the other hand, PTX3 was not significantly correlated with HbA1c and UAE but significantly negatively correlated with PAC in patients with diabetes. Therefore, it might be suggested that PTX3 is positively regulated by chronic hyperglycemia but negatively regulated by aldosterone, and is associated with urinary albumin excretion as a micro vasculopathy.

Highlights

Pentraxins are superfamily of acute-phase proteins that induce short pentraxins such as C-reactive protein (CRP) or long pentraxins such as pentraxin 3 (PTX3) [1]
Serum high-sensitive CRP level was higher in patients with diabetes (P = 0.003) and Maximum carotid intima-media thickness (max IMT) was lower in patients with primary aldosteronism (PA) (P = 0.024)
We have shown the significant correlation between PTX3 and existence of diabetes, HbA1c, urinary albumin excretion (UAE), plasma aldosterone concentration (PAC) and high-sensitive CRP in total population of this study

Summary

Introduction

Pentraxins are superfamily of acute-phase proteins that induce short pentraxins such as C-reactive protein (CRP) or long pentraxins such as pentraxin 3 (PTX3) [1]. It was shown that serum PTX3 level was positively correlated with atherosclerotic markers in patients with diabetes [10,11]. Serum PTX3 level was correlated with insulin resistance in patients with obesity or polycystic ovary syndrome [12,13]. PTX3 was reported to promote insulin sensitivity in obese mice model [14]. It was reported that PTX3 was a specific marker of ischemic heart disease [15,16,17,18] or Takayasu arteritis [19]. It was reported that PTX3 was negatively correlated with atherosclerotic markers in patients with obesity [23,24] or gestational diabetes mellitus (GDM) [25]. The significance and function of PTX3 as a vascular inflammation marker are still controversial

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Results

Conclusion