Abstract
Acute pancreatitis (AP) is a leading cause of gastrointestinal hospital admissions with up to 40% mortality in moderate to severe AP. 1 Boxhoorn L. et al. Lancet. 2020; 396: 726-734 Abstract Full Text Full Text PDF PubMed Scopus (221) Google Scholar Cell death and inflammation are key processes in the pathophysiology of AP, and mitochondria-mediated cell death plays a central role in the initiation of inflammatory pathways of AP. 2 Krysko D.V. et al. Trends Immunol. 2011; 32: 157-164 Abstract Full Text Full Text PDF PubMed Scopus (483) Google Scholar Evidence suggests that several damage-associated molecular patterns (DAMPs) are released from dead pancreatic acinar mitochondria into the extracellular circulation. Given the need for early diagnosis of AP severity for proper treatment, we investigated whether circulating levels of mitochondrial DNA (mtDNA) fragments are a potential biomarker of early distinction for AP severity.
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