Abstract
The search for novel non-invasive biomarkers such as epigenetic molecular markers is new hope for common and burdensome cancers. We aim to assess serum expression of miRNA 27a and miRNA150-5p in endometrial cancer patients. Serum was drawn for 36 un-intervened endometrial cancer patients scheduled for hysterectomy and 35 controls. miRNA 27a and miRNA150-5p were measured by real time reverse transcription polymerase chain reaction. Significant overexpression of both miRNA in patients (p < 0.001). At cutoffs 0.2872 & > 1.02, miRNA 27a showed 100% sensitivity, specificity, positive and negative predictive values. miRNA150-5p showed 88.89% sensitivity, 100% specificity, 100% positive and 78.9% negative predictive values. Areas under curve were 1.0 for miRNA 27a, 0.982 for miRNA 150 performing much better than Ca125. miRNA 27a was significantly associated with type I endometroid endometrial cancer. Conclusion: miRNA 27a and miRNA-150-5P can be suggested as promising biomarkers of endometrial cancer possibly part of a miRNA panel for management.
Highlights
Endometrial cancer (EC) incidence has doubled in the last 20 years with the increasing burden of obesity and is expected to increase in developing countries
Serum was drawn for 36 un-intervened endometrial cancer patients scheduled for hysterectomy & 35 controls. miRNA 27a and miRNA150-5p were measured by real time reverse transcription polymerase chain reaction
Areas under curve were 1.0 for miRNA 27a, 0.982 for miRNA 150 performing much better than Ca125. miRNA 27a was significantly associated with type I endometroid endometrial cancer
Summary
Endometrial cancer (EC) incidence has doubled in the last 20 years with the increasing burden of obesity and is expected to increase in developing countries. Incidence has increased steadily due to changes in lifestyle of women, delayed marriage and decreased gravidity, which make it one of the major lethal cancer of all gynecologic malignancies. It is the most common female genital tract malignancy worldwide, and its prevailing histological type is endometrial endometrioid adenocarcinoma. Ca125 is as a serum marker for EC diagnosis and screening but is recognized to have poor specificity as other gynecologic malignancies such as ovarian cancer can show the raise of Ca125. MiRNAs target messenger RNAs (mRNAs) via sequence specific interaction to repress translation or degrade target mRNA [9]. We aim to assess serum expression of miRNA 27a and miRNA150-5p in endometrial cancer patients
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