Abstract

Purpose: There is an outstanding need to identify minimally invasive biomarkers for reliable detection of knee osteoarthritis (OA). Current clinical diagnostic methods are limited since OA symptoms do not always correlate with structural degeneration in the joint. Soluble biochemical markers provide a better readout of disease activity, and a variety of blood, synovial fluid, and urine biomarkers have been explored in OA, including microRNAs. As small, non-coding RNAs, microRNAs are promising biomarker candidates since they are easy to detect in biofluids, are relatively stable (i.e.

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