Abstract
The purpose of this study was to find the circulating microRNAs (miRNAs) co-related with the severity of coronary artery calcification (CAC), and testify whether the selected miRNAs could reflect the obstructive coronary artery disease in symptomatic patients. Patients with chest pain and moderated risk for coronary artery disease (CAD) were characterized with coronary artery calcium score (CACS) from cardiac computed tomography (CT). We analyzed plasma miRNA levels of clinical matched 11 CAC (CACS > 100) and 6 non-CAC (CACS = 0) subjects by microarray profile. Microarray analysis identified 34 differentially expressed miRNAs between CAC and non CAC groups. Eight miRNAs (miR-223, miR-3135b, miR-133a-3p, miR-2861, miR-134, miR-191-3p, miR-3679-5p, miR-1229 in CAC patients) were significantly increased in CAC plasma in an independent clinical matched cohort. Four miRNAs (miR-2861, 134, 1229 and 3135b) were correlated with the degree of CAC. Validation test in angiographic cohort showed that miR-134, miR-3135b and miR-2861 were significantly changed in patients with obstructive CAD . We identified three significantly upregulated circulating miRNAs (miR-134, miR-3135b and 2861) correlated with CAC while detected obstructive coronary disease in symptomatic patients.
Highlights
MiRNAs have been reported for cardiac hypertrophy[9], acute myocardial infarction (AMI)[10,11,12], heart failure[13], coronary artery disease[14], and diabetes mellitus (DM)[15]
We investigated the association of certain plasma circulating miRNAs with coronary calcification and their clinical significance
We characterize the circulating miRNA profile in CAC patients and identify circulating miRNAs which can best reflect the level of CAC in symptomatic patients with moderate risk of coronary artery disease (CAD) and further tested whether those miRNA can detect the presence of obstructive CAD
Summary
MiRNAs have been reported for cardiac hypertrophy[9], acute myocardial infarction (AMI)[10,11,12], heart failure[13], coronary artery disease[14], and diabetes mellitus (DM)[15]. Signatures of circulating miRNAs have not been characterized in individuals with CAC, which is the subject of this study
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