Abstract
To determine circulating levels of placental protein 14 (PP14) in complications of early pregnancy. Biochemical monitoring of women presenting with vaginal bleeding and/or abdominal pain. An emergency gynaecological ultrasound clinic in a London teaching hospital. Venous blood samples were obtained from 67 women with normal pregnancy (n = 9), ectopic pregnancy (n = 26) and failed intrauterine pregnancy (n = 32). This group included anembryonic pregnancy (n = 18), missed miscarriage (n = 2), spontaneous miscarriage of a previously demonstrated live fetus (n = 6), incomplete miscarriage (n = 4), complete miscarriage (n = 1) and molar pregnancy (n = 1). Serum PP14 levels in the group of women with a failed intrauterine pregnancy in relation to the normal range for PP14. Eighty-one percent of women who miscarried spontaneously had normal serum PP14 levels; 81% of women with ectopic pregnancy had depressed (< 5th centile) serum PP14 levels. Measurements of PP14 may be useful in distinguishing spontaneous miscarriage from ectopic pregnancy, but not in the management of threatened miscarriage.
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