Abstract
Abstract Background/aims Irisin is a hormone expressed in muscle, which is an exercise-induced myokine triggering browning of white adipose tissue and increases metabolic genes expression. Methods We investigated the irisin levels in 39 type 2 diabetes mellitus patients (T2D) compared to 39 control individuals. Results Irisin plasma levels were higher in T2D patients when compared with the control group ( p p p =0.011, respectively). Obese T2D individuals showed higher irisin levels when compared with non-obese control ( p =0.003), but no difference was observed when compared with obese controls ( p >0.05). A positive correlation was observed between irisin and fasting glucose levels in the T2D group ( r =0.341, p =0.033). No difference regarding irisin levels was found when T2D individuals who practice physical activity and sedentary individuals were compared ( p =0.632). Conclusion This result indicates that T2D is associated with an irisin release in order to compensate the insulin resistance observed in the skeletal muscle on diabetes, and that the poor glycaemic control contributes for enhancement of this state.
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