Abstract
Background/aimsIrisin is a myokine, which is mainly inversely associated with the risk for non-communicable diseases. Irisin improves cellular energy metabolism by uncoupling the mitochondrial respiratory chain resulting in increased energy expenditure using lipids. To date potential associations between irisin concentration and lipid profile are poorly understood. Therefore, this investigation aimed to evaluate potential associations between irisin and lipid levels in the general population.MethodsData of 430 men and 537 women from the population-based Study of Health in Pomerania (SHIP-TREND) with available irisin and lipid concentrations were used. Analyses of variance, linear and logistic regression models adjusted for age, HBA1c, waist circumference, physical activity, smoking, alcohol consumption, systolic blood pressure, ALAT were calculated.ResultsWe detected significantly inverse associations between irisin and circulating levels of total [beta coefficient 0.21 (standard error 0.08), p = 0.01], low-density cholesterol [-0.16 (0.07), p = 0.03] and triglycerides [-0.17 (0.08), p = 0.02] for men. Females without lipid lowering medication had an inverse association between irisin and total cholesterol [-0.12 (0.06), p = 0.05]. Further, male subjects with irisin concentrations in the third tertile had an increased odds for elevated low-density cholesterol [odds ratio 1.96 (95% confidence interval 1.07–3.48), p = 0.03) and triglyceride [1.95 (1.09–3.47), p = 0.02] levels, even after exclusion of subjects with lipid lowering medication. In addition, our data revealed an annual rhythm of serum irisin levels with peak levels arise in winter and summer months.ConclusionThis is the first investigation to report a significant association between circulating irisin and a favourable lipid profile in the general population. This may infer that higher irisin concentrations are associated with a reduced risk for non-communicable diseases.
Highlights
Irisin is a metabolite secreted by myocytes and upregulated after moderate aerobic endurance exercise [1]
Our data revealed an annual rhythm of serum irisin levels with peak levels arise in winter and summer months
This is the first investigation to report a significant association between circulating irisin and a favourable lipid profile in the general population
Summary
Irisin is a metabolite secreted by myocytes and upregulated after moderate aerobic endurance exercise [1]. A potential explanation for the conflicting results is that irisin may not be exclusively secreted by skeletal muscle, and by the perimysium, endomysium and nerve sheaths [6]. Exercise induced irisin release by skeletal muscle has been investigated previously. While the release of irisin in response to exercise from skeletal muscle is under debate, several physiological functions have been identified. Type 2 diabetes mellitus (T2DM) is associated with reduced irisin levels [8]. No linear association between irisin concentration and NAFLD was found but rather an initial increase followed by a decrease with the progression of the disease [9]. The established role of irisin in whole body homeostasis suggests a therapeutic potential for the treatment of T2DM and obesity [1]
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