Circulating Hepatocyte Growth Factor Reflects Activation of Vascular Repair in Response to Stress

Abstract

Hepatocyte growth factor (HGF) is released by stressed human vascular cells and promotes vascular cell repair responses in both autocrine and paracrine ways. Subjects with a low capacity to express HGF in response to systemic stress have an increased cardiovascular risk. Human atherosclerotic plaques with a low content of HGF have a more unstable phenotype. The present study shows that subjects with a low abilityto express HGF in response to metabolic stress have an increased risk to suffer myocardial infarction and stroke.