Abstract
BackgroundInsulin-like growth factor 1 (IGF-1) and binding protein 3 (IGFBP-3) are associated with breast cancer in women at average risk of cancer. Less is known whether these biomarkers also predict risk in women with breast cancer family history.MethodsWe conducted a nested case-control study within the New York site of the Breast Cancer Family Registry (BCFR, n = 80 cases, 156 controls), a cohort enriched for breast cancer family history. Using conditional logistic regression, we estimated the association between IGF-1 and IGFBP-3 levels and breast cancer risk and examined whether this risk differed by predicted absolute breast cancer risk based on pedigree models.ResultsThe overall association between IGF-1 or IGFBP-3 elevation (≥ median in controls) and breast cancer risk was elevated, but not statistically significant (IGF-1 OR = 1.37, 95% CI = 0.66–2.85; IGFBP-3 OR = 1.62, 95% CI = 0.81–3.24). Women with elevated predicted absolute 10-year risk ≥ 3.4% and elevated IGFBP-3 (≥ median) had more than a 3-fold increased risk compared to women with lower predicted absolute 10-year risk (< 3.4%) and low IGFBP-3 (OR = 3.47 95% CI = 1.04–11.6).ConclusionsThese data offer some support that the overall magnitude of the associations between IGF-1 and IGFBP3 seen in average risk cohorts may be similar in women enriched with a strong breast cancer family history.
Highlights
Insulin-like growth factor 1 (IGF-1) and binding protein 3 (IGFBP-3) are associated with breast cancer in women at average risk of cancer
The risk of breast cancer was elevated across models with continuous biomarker measures except for the adjusted model for continuous IGF-1 (OR = 0.77, 95% Confidence interval (CI) 0.26–2.31, Table 2)
We saw increased risk with elevated biomarker levels, with an OR of 1.37 in the adjusted model for elevated IGF-1 and an OR of 1.62 for elevated Insulinlike growth factor binding protein 3 (IGFBP-3) (Table 2)
Summary
Insulin-like growth factor 1 (IGF-1) and binding protein 3 (IGFBP-3) are associated with breast cancer in women at average risk of cancer. Less is known whether these biomarkers predict risk in women with breast cancer family history. Insulin-like growth factor (IGF-1) and its primary binding protein (IGFBP-3) are known risk factors for breast cancer due to their ability to stimulate mitosis and suppress programmed cell death [1]. Studies have shown that both breast cancer development and recurrence are Monson et al Breast Cancer Research (2020) 22:109 and breast cancer across the spectrum of predicted absolute breast cancer risk
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