Abstract
Background. Endothelial Microparticles (EMPs) are small vesicles shed from activated or apoptotic endothelial cells and involved in cellular cross-talk. Whether EMP immunophenotypes vary according to stimulus in Diabetes Mellitus (DM) is not known. We studied the cellular adhesion molecule (CAM) profile of circulating EMPs in patients with and without Diabetes Mellitus type 2, who were undergoing elective cardiac catheterization. Methods and Results. EMPs were analyzed by flow cytometry. The absolute median number of EMPs (EMPs/μL) specific for CD31, CD105, and CD106 was significantly increased in the DM population. The ratio of CD62E/CD31 EMP populations reflected an apoptotic process. Conclusion. Circulating CD31+, CD105+, and CD106+ EMPs were significantly elevated in patients with DM. EMPs were the only independent predictors of DM in our study cohort. In addition, the EMP immunophenotype reflected an apoptotic process. Circulating EMPs may provide new options for risk assessment.
Highlights
Endothelial microparticles (EMPs) are an emerging marker of endothelial cell (EC) dysfunction, and their circulating numbers are elevated in a number of pathologic states including cardiovascular disease [1]
We demonstrated that Diabetes Mellitus (DM) is associated with increased levels of circulating Endothelial Microparticles (EMPs)
Circulating EMPs are associated with the presence of high-risk angiographic lesions, including eccentric type II, multiple irregular, and lesions with thrombi; we found no significant relation of EMP levels with the presence or severity of CAD [9, 20]
Summary
Endothelial microparticles (EMPs) are an emerging marker of endothelial cell (EC) dysfunction, and their circulating numbers are elevated in a number of pathologic states including cardiovascular disease [1]. Studies demonstrate that, EMPs correlate in vivo with indices of EC dysfunction, the presence of coronary artery disease and with the complications of Diabetes Mellitus type 2 (DM) [5, 6]. Endothelial Microparticles (EMPs) are small vesicles shed from activated or apoptotic endothelial cells and involved in cellular cross-talk. We studied the cellular adhesion molecule (CAM) profile of circulating EMPs in patients with and without Diabetes Mellitus type 2, who were undergoing elective cardiac catheterization. The ratio of CD62E/CD31 EMP populations reflected an apoptotic process. The EMP immunophenotype reflected an apoptotic process.
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
