Abstract
BackgroundPrevious animal studies have revealed that CTRP7 is related to energy metabolism. However, little is known regarding the relationship between CTRP7 and metabolic diseases in humans. Hence, this study was designed to explore the association between CTRP7 and MetS through a cross-sectional study and multiple intervention studies.MethodsA total of 624 individuals were enrolled in this study. The levels of CTRP7 and APN were determined by ELISA kit. HEC, OGTT and lipid infusion were performed in heathy individuals to investigate the association of CTRP7 and glucose, insulin and FFA. Bioinformatics analysis was then undertaken to identify genes and signaling pathways associated with CTRP7. The relationship between CTRP7 with MetS components was also evaluated.ResultsIn MetS patients, serum CTRP7 concentrations were significantly higher than in healthy controls, and was positively correlated with WC, BP, FBG, 2h-BG and TG, but negatively correlated with HDL-C and APN. Multivariate logistic regression analysis uncovered that CTRP7 was strongly correlated with the occurrence of MetS. In addition, circulating levels of CTRP7 in patients with two or more MetS components were higher than those with one MetS component. In the intervention studies, OGTTs resulted in a significant reduction in serum CTRP7 concentration. However, the increase in insulin levels caused by EHC and the increase of FFA caused by lipid-infusion led to the significant increase of serum CTRP7 concentration. Meanwhile, bioinformatics analysis revealed that CTRP7 was strongly associated with metabolism-related genes and signal pathways, which further illustrate the association of CTRP7 with whole-body metabolism.ConclusionsSerum CTRP7 is increased in MetS patients, which may be a biomarker related to metabolic diseases.Clinical Trial Registration NumberChiCTR2000032878
Highlights
Metabolic syndrome (MetS), known as insulin resistance (IR) syndrome, was first described in 1988
The increase in insulin levels caused by euglycemic-hyperinsulinemic clamps (EHC) and the increase of free fatty acid (FFA) caused by lipid-infusion led to the significant increase of serum CTRP7 concentration
Bioinformatics analysis revealed that CTRP7 was strongly associated with metabolism-related genes and signal pathways, which further illustrate the association of CTRP7 with whole-body metabolism
Summary
Metabolic syndrome (MetS), known as insulin resistance (IR) syndrome, was first described in 1988. It represents an aggregation of cardiovascular risk factors. IR, obesity, impaired glucose tolerance (IGT), dyslipidemia, hypertension, and chronic low-grade inflammation are all considered characteristics of MetS [1,2,3,4]. MetS classification has important clinical significance and application value for screening metabolic diseases related to obesity [5]. Because characteristics of MetS include chronic low-grade inflammation and IR, it is important to study the biomarkers for prevention and diagnosis as well as finding new drug targets. The CTRP family may be an important biomarker of metabolic diseases in humans. This study was designed to explore the association between CTRP7 and MetS through a cross-sectional study and multiple intervention studies
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