Abstract
To determine the relationship of coxsackievirus A16 (CA16) to prototype CA16-G10, we conducted a phylogenetic analysis of circulating CA16 strains in China. Complex recombinant forms of CA16-related viruses involving multiple human enteroviruses, subgroup A (CA4, CA16, and enterovirus 71), are prevalent among patients with hand, foot, and mouth disease.
Highlights
To determine the relationship of coxsackievirus A16 (CA16) to prototype CA16-G10, we conducted a phylogenetic analysis of circulating CA16 strains in China
We found that current CA16 strains in China, still related to CA16–G10, are recombinant Human enterovirus (HEV)-A
Phylogenetic analysis, performed with the MEGA4 program [12], indicated that CA16 strains shzh00-1, shzh05-1, and GZ08 did not cluster with CA16-G10 (Figure 1, panel A), they belonged to HEV-A and clustered with EV71A (BrCr), EV71B (EV71/9/97/SHA89), and EV71C (S10862SAR-98) (Table)
Summary
To determine the relationship of coxsackievirus A16 (CA16) to prototype CA16-G10, we conducted a phylogenetic analysis of circulating CA16 strains in China. Partial viral sequencing (e.g., of the viral protein [VP] 1 region), serologic characterization, or both, have shown that 10%–50% of viruses from HFMD patients are related to prototype CA16-G10, and they have been classified as CA16 strains [11]. We found that current CA16 strains in China, still related to CA16–G10, are recombinant HEV-A.
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