Abstract
Corin, a type II transmembrane serine protease, is expressed almost exclusively by cardiomyocytes [ 1 Yan W. Sheng N. Seto M. Morser J. Wu Q. Corin, a mosaic transmembrane serine protease encoded by a novel cDNA from human heart. J. Biol. Chem. 1999; 274: 14926-14935 Crossref PubMed Scopus (220) Google Scholar , 2 Hooper J.D. Scarman A.L. Clarke B.E. Normyle J.F. Antalis T.M. Localization of the mosaic transmembrane serine protease corin to heart myocytes. Eur. J. Biochem. 2000; 267: 6931-6937 Crossref PubMed Scopus (88) Google Scholar ]. It converts the precursor molecules of A- and B-type natriuretic peptides into active proteins [ [3] Knappe S. Wu F. Madlansacay M.R. Wu Q. Identification of domain structures in the propeptide of corin essential for the processing of proatrial natriuretic peptide. J. Biol. Chem. 2004; 279: 34464-34471 Crossref PubMed Scopus (69) Google Scholar ]. Thus, corin plays a key role in the regulation of blood volume, blood pressure and cardiac function. Corin is shed from the myocyte cell surface and enters circulation, a process that might reflect homeostasis within the heart [ [4] Dong N. Chen S. Yang J. et al. Plasma soluble corin in patients with heart failure. Circ. Heart Fail. 2010; 3: 207-211 Crossref PubMed Scopus (123) Google Scholar ]. Recently, plasma corin concentrations were shown to be lower in patients with heart failure compared to healthy controls [ [5] Ibebuogu U.N. Gladysheva I.P. Houng A.K. Reed G.L. Decompensated heart failure is associated with reduced corin levels and decreased cleavage of pro-atrial natriuretic peptide. Circ Heart Fail. 2011; 4: 114-120 Crossref PubMed Scopus (99) Google Scholar ]. Chronic loss of cardiomyocytes as well as reduced corin synthesis and shedding might be responsible for this finding.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
