Abstract
BackgroundAngiogenesis is an important process involved in the pathogenesis of diffuse parenchymal lung diseases. The aim of the study was to compare the angiogenic profile of patients with sarcoidosis and idiopathic pulmonary fibrosis (IPF) based on analysis of circulating factors.MethodsSerum concentrations of angiopoietin-2 (Ang-2), follistatin, granulocyte-macrophage-colony stimulating factor (GM-CSF), interleukin-8 (IL-8), platelet derived growth factor-BB (PDGF-BB), platelet endothelial cellular adhesion molecule-1 (PECAM-1) and vascular endothelial growth factors (VEGF) were measured in the patients and the healthy subjects.ResultsSerum concentrations of G-CSF, follistatin, PECAM-1 and IL-8 were significantly higher in the IPF patients in comparison with the control group and the sarcoid patients. PDGF-BB concentrations were also significantly higher in serum of IPF patients than in sarcoid patients, but not than in the controls. In contrast, Ang-2 and VEGF concentrations did not differ significantly between the three groups. In the sarcoid patients, irrespective of the disease activity or the radiological stage, serum concentrations of these cytokines were similar to the control group.ConclusionsThese results indicate that differences may exist in angiogenic activity between patients with parenchymal lung diseases. In contrast to sarcoidosis, IPF is characterized by a higher serum concentration of different molecules involved in the angiogenic processes .
Highlights
Angiogenesis is an important process involved in the pathogenesis of diffuse parenchymal lung diseases
In the idiopathic pulmonary fibrosis (IPF) patients, serum Ang-2 and vascular endothelial growth factor (VEGF) concentrations did not differ significantly from these obtained in the sarcoid group and the controls (Table 2 and Figs. 1, 2, 3, 4, 5, 6, and 7)
In the IPF group we found statistically significant correlations between concentrations of Ang-2 and interleukin 8 (IL-8) (r = 0.62, P < 0.01), follistatin and platelet endothelial cellular adhesion molecule-1 (PECAM-1) (r = 0.83, P < 0.0001) and platelet derived growth factor-BB (PDGF-BB) and VEGF (r = 0.7, P < 0.01)
Summary
Angiogenesis is an important process involved in the pathogenesis of diffuse parenchymal lung diseases. Angiogenesis, defined as the process of growth of new blood vessels, plays a pivotal role in wound healing and. Among various markers of angiogenesis, angiopoietin (Ang-2), follistatin, granulocyte-macrophage-colony stimulating factor (GM-CSF), interleukin 8 (IL-8), platelet derived growth factor-BB (PDGF-BB), platelet endothelial cellular adhesion molecule-1 (PECAM-1) and vascular endothelial growth factor (VEGF), seem to be involved in different steps of physiological and pathological angiogenic processes, such as proliferation, maturation and survival of new blood vessels. Ang-2, which is part of a family of vascular growth factors that play a role in embryonic and postnatal angiogenesis and is involved in controlling microvascular permeability, vasodilation, and vasoconstriction by. IL-8, known as a neutrophil chemotactic factor and produced by macrophages, epithelial cells, airway smooth muscles and endothelial cells, is a potent promoter of angiogenesis [9]
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