Circulating Clusterin and Osteopontin Levels in Asthma and Asthmatic Pregnancy.

Brigitta Dombai,András Bikov,Barna Vásárhelyi,István Ivancsó,Veronika Müller,János Rigó,Dóra Oroszi,Anikó Bohács,Lilla Tamási,György Losonczy

doi:10.1155/2017/1602039

Brigitta Dombai, András Bikov + Show 8 more

Open Access

https://doi.org/10.1155/2017/1602039

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Abstract

Asthma in pregnancy poses a risk of adverse outcomes. Osteopontin and clusterin emerged as asthma biomarkers; however, their circulating levels during pregnancy are unknown yet. This cross-sectional study investigated peripheral osteopontin and clusterin levels and their relationship to disease control in 26 asthmatic pregnant (AP), 22 asthmatic nonpregnant (ANP), and 25 healthy pregnant (HP) women and 12 healthy controls (HNP). Osteopontin levels of ANP and HNP were similar (2.142 [1.483–2.701] versus 2.075 [1.680–2.331] ng/mL, p = 0.7331). Pregnancy caused a marked elevation in both healthy (HP: 3.037 [2.439–4.015] ng/ml, p = 0.003 versus HNP) and asthmatic (AP: 2.693 [1.581–3.620] ng/ml) patients; thus the pregnant groups did not differ (p = 0.3541). Circulating clusterin levels were comparable in ANP and HNP (109.2 [95.59–116.3] versus 108.8 [97.94–115.3] µg/mL, p = 0.8730) and the level was lower in HP (98.80 [84.26–105.5] µg/mL, p = 0.0344 versus HNP). In contrast, the level was higher in AP (111.7 [98.84–125.6] µg/mL, p = 0.0091 versus HP). In ANP, a positive correlation of PEF (r = 0.3405; p = 0.0221) and a negative correlation of Raw (r = −0.3723; p = 0.0128) to clusterin level were detected. Circulating osteopontin level increases in pregnancy regardless of concomitant well-controlled asthma, indicating its gestational role. Clusterin level decreases in healthy but not in asthmatic pregnancy and correlates directly with lung function.

Highlights

Asthma is one of the most common chronic diseases complicating pregnancy [1, 2], occurring in 8–12% of all gestations [3]
Since this pregnancy-specific decrease was absent in asthmatic pregnant (AP) group (AP 111.7 [98.84–125.6] versus asthmatic nonpregnant (ANP) 109.2 [95.59–116.3] μg/mL), we could demonstrate a significant difference between the clusterin levels of the two pregnant groups (111.7 [98.84–125.6] μg/mL in AP versus 98.80 [84.26–105.5] μg/mL in healthy pregnant (HP), p = 0.0091; Figure 3 and Table 1)
We examined any possible relationships between these markers and asthma control determinants

Summary

Introduction

Asthma is one of the most common chronic diseases complicating pregnancy [1, 2], occurring in 8–12% of all gestations [3]. The rising level of osteopontin during pregnancy and its relation to the number of recruited decidual NK cells [26] suggest that it has an important role in the maintenance of a successful pregnancy This idea is supported even further by some studies that detected lower osteopontin levels in pregnant women with preeclampsia and unexplained recurrent miscarriage [26, 27]. Circulating clusterin concentration was found to be elevated in patients with severe asthma, and it showed an inverse correlation with lung function; clusterin was considered an indicator of oxidative stress rather than a protective factor [30] It correlated with the age of the patients and showed a significant decrease in steroid-naıve patients with the initiation of ICS therapy [30]. The possible relationships between osteopontin, clusterin, and asthma control determinants were evaluated

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