Abstract
Sarcopenia is an age-related loss of muscle mass and function, leading to disability, morbidity and increased mortality in older people. Given the relatively high prevalence and related- outcome of the disease, correct diagnosis, screening, monitoring and treatment of sarcopenia are needed in clinical practice. Recent researches have focused on cell-free nucleic acids, which are released into the circulation following cell death, as a potential biomarker of aging and systematic inflammation. It seems that the diagnosis and treatment of sarcopenia can be possible by the help of the analysis of cell-free nucleic acids as noninvasive method.
Highlights
BackgroundSarcopenia, a multifactorial geriatric syndrome, is characterized by age-related decline in muscle mass and function [1]
Recent advances in technologies provide an extraordinary capacity to characterize the genetic alterations and pathways in diseases comprehensively and make it possible to develop therapies, prevention and screening based on the genetic makeup of each disease [10].Circulating cell- free nucleic acids in various body fluids have been explored as a novel biomarker in a variety of clinical conditions
The first studies concerning the detection of circulating cell free DNA was found in various cancers, metastasis and recurrence
Summary
Sarcopenia, a multifactorial geriatric syndrome, is characterized by age-related decline in muscle mass and function [1]. There are multiple intrinsic (biological changes, inflammatory states; etc.) and extrinsic (decreased activity, malnutrition; etc.) factors that participate in the development of sarcopenia [2]. Given the relatively high prevalence and related- outcome of the disease, correct diagnosis, screening, monitoring and treatment of sarcopenia are needed in clinical practice as well as for the conductance of beneficial interventions. In this regard, the global quantitative data from both genetic, biomarkers and body composition could provide a standardized and international comparable readout for successful care. Several biological markers have been found to be associated with age-related skeletal muscle decline, but they are not specific to muscle
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