Abstract
Mitral valve is mostly affected in rheumatic heart disease which is prevalent in developing countries [1–3] and thousands of new cases are being diagnosed worldwide every year [1–3]. It is known that extensive fibrosis occurs in the rheumatic valve [4]. Serum carboxyterminal propeptide of type I procollagen (PICP), the marker of collagen synthesis was reported as a marker of extracellular matrix (ECM) remodelling in various heart diseases [5–8]. We therefore, measured the levels of circulating PICP to explore the severity of ECM remodelling in rheumatic heart disease.
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