Abstract
Synthetized by the liver and metabolized by the gut microbiota, BA are involved in metabolic liver diseases that are associated with cardiovascular disorders. Animal models of atheroma documented a powerful anti-atherosclerotic effect of bile acids (BA). This prospective study examined whether variations in circulating BA are predictive of coronary artery disease (CAD) in human. Consecutive patients undergoing coronary angiography were enrolled. Circulating and fecal BA were measured by high pressure liquid chromatography and tandem mass spectrometry. Of 406 screened patients, 80 were prospectively included and divided in two groups with (n = 45) and without (n = 35) CAD. The mean serum concentration of total BA was twice lower in patients with, versus without CAD (P = 0.005). Adjusted for gender and age, this decrease was an independent predictor of CAD. In a subgroup of 17 patients, statin therapy doubled the serum BA concentration. Decreased serum concentrations of BA were predictors of CAD in humans. A subgroup analysis showed a possible correction by statins. With respect to the anti-atherosclerotic effect of BA in animal models, and their role in human lipid metabolism, this study describe a new metabolic disturbance associated to CAD in human.
Highlights
Synthetized by the liver and metabolized by the gut microbiota, bile acids (BA) are involved in metabolic liver diseases that are associated with cardiovascular disorders
They are metabolized by the microbiota, consisting of a bacterial deconjugation followed by a transformation, leading to the secondary deoxycholic acid (DCA) and lithocholic acid (LCA)[13]
The objective of this work was to determine in humans whether there are observable qualitative or quantitative differences in circulating and fecal bile acids, and in the composition of the microbiota during coronary artery disease (CAD)
Summary
Synthetized by the liver and metabolized by the gut microbiota, BA are involved in metabolic liver diseases that are associated with cardiovascular disorders. Animal models of atheroma documented a powerful anti-atherosclerotic effect of bile acids (BA) This prospective study examined whether variations in circulating BA are predictive of coronary artery disease (CAD) in human. By modifying the stereospatial configuration of BA, the microbiota directly influences the composition of the bile acids p ool[13], as well as their binding and activation properties to their specific r eceptors[14,15] This loop is closed when 95% of the BA are reabsorbed in the ileum, returning to the liver via the portal circulation. Atherosclerosis is more than a mere aging process, implying the participations of pro-inflammatory and metabolic disorders[1]: several studies in animals and humans have linked the stimulation of BA receptors to other beneficial metabolic effects, in energy e xpenditure[22] or glucido-lipid metabolism[6]
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
