Abstract
PurposePrevious researches of betatrophin on glucose and lipids metabolism under insulin-resistant condition have reached controversial conclusions. To further identify the possible impact of betatrophin, we measured the circulating betatrophin levels in newly diagnosed type 2 diabetes (T2DM) patients, and in subjects with both impaired glucose tolerance (IGT) and normal glucose tolerance (NGT) and investigated the relationship between serum betatrophin and other clinical parameters in these patients with different glucose tolerance statuses.MethodsA total of 460 permanent residents of the Fengxian District, aged 40–60 years, were enrolled. Based on the results of a 75 g oral glucose tolerance test, we selected newly diagnosed T2DM (n = 50) patients and subjects with IGT (n = 51) and NGT (n = 50) according to their age, gender and body mass index (18–28 kg/m2). Anthropometric parameters, glycosylated haemoglobin, blood lipids and fasting insulin were measured. Serum betatrophin concentrations were determined via ELISA.ResultsSerum betatrophin levels in T2DM patients were increased significantly compared with IGT and NGT groups, and decreased in subjects with better islet beta cell function. Serum betatrophin was positively correlated with triglyceride, 2-hour postprandial glucose, alanine aminotransferase and aspartate transaminase after adjusting for age, sex and body mass index in all subjects. Multiple regression analysis showed that 2-hour postprandial glucose was independently associated with serum betatrophin significantly.ConclusionsCirculating betatrophin is increased in newly-diagnosed T2DM patients and positively correlated with the triglycerides and postprandial glucose levels. The results suggest that betatrophin may participate in glucose and triglycerides metabolism.
Highlights
The prevalence of diabetes mellitus, which is a major public health issue, has been increasing dramatically over the last decade
Serum betatrophin levels in type 2 diabetes mellitus (T2DM) patients were increased significantly compared with impaired glucose tolerance (IGT) and normal glucose tolerance (NGT) groups, and decreased in subjects with better islet beta cell function
Serum betatrophin was positively correlated with triglyceride, 2-hour postprandial glucose, alanine aminotransferase and aspartate transaminase after adjusting for age, sex and body mass
Summary
The prevalence of diabetes mellitus, which is a major public health issue, has been increasing dramatically over the last decade. T2DM is characterized by beta cell dysfunction and insulin resistance. In a mouse model of insulin resistance developed via the administration of S961, Yi observed an increase in islet beta cell proliferation induced by the over-expression of betatrophin [4]. Gusarova [5] raised doubt by revealing that over-expression of angptl in mice doubles plasma triglyceride levels, but does not alter beta cell expansion. Espes observed an increased circulating betatrophin concentration in patients with long-standing type 1 diabetes [6], and studies on T2DM demonstrated that serum betatrophin was increased in T2DM patients [7,8].
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