Abstract
Circulating levels of immunoreactive atrial natriuretic peptides (ir-ANP) were measured in conscious young (4-week-old) and adult (16-week-old) spontaneously hypertensive rats (SHR) and in age-matched Wistar-Kyoto (WKY) rats under basal conditions and following acute blood volume expansion or acute salt loading. Independent of resting blood pressure levels, basal plasma concentrations of ir-ANP were similar in age-matched SHR and WKY rats. Acute blood volume expansion increased circulating levels of ir-ANP dose dependently in both strains. In adult rats the release of ANP after acute blood volume expansion was correlated with increments in right atrial pressure. The volume-stimulated release of ANP was markedly attenuated in young SHR compared to age-matched WKY rats, suggesting increased venous and/or cardiac compliance in the former.
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