Abstract
In a cross-sectional study circulating levels of antithrombins, antithrombin III, alpha 1-antitrypsin and alpha 2-macroglobulin were measured in groups of 20 women before pregnancy, during each trimester and post partum. Blood levels of antithrombin III were significantly lower, alpha 1-antitrypsin higher and alpha 2-macroglobulin no different when compared with those of the non-pregnant and puerperal states. These findings suggest that there may be not only an increase in total antithrombin production, but also a qualitative change in antithrombin 'activity', the principal protein during pregnancy being alpha 1-antitrypsin.
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