Circulating Angiogenic T Cells and Their Subpopulations in Patients with Systemic Lupus Erythematosus.

Jinlin Miao,Xiaokun Qi,Ping Zhu,Kui Zhang,Minghua Lv,Peng Zhao,Tingting Li,Feng Qiu,Jun Wan

doi:10.1155/2016/2842143

Abstract

Objective. Systemic lupus erythematosus (SLE) is associated with accelerated atherosclerosis and increased cardiovascular risk. Angiogenic T cells (Tang), a specific T cell subset, have been identified and involved in the repair of damaged endothelium. This study aimed to analyze the Tang cell subsets in relation to disease specific features from SLE patients. Methods. Tang cell subsets were assessed in peripheral blood samples from 41 SLE patients and 22 healthy controls (HC) by flow cytometry on the basis of CD31 and CXCR4 expression on CD3+, CD4+, and CD8+ T cells. Results. The percentage of circulating CD8+CD31+CXCR4+ T cells (CD8+ Tang), but not CD3+CD31+CXCR4+ T cells (Tang) and CD4+CD31+CXCR4+ T cells (CD4+ Tang), in SLE was higher than HC. The percentages of Tang cell subsets in anti-dsDNA-positive SLE patients were significantly increased as compared to their negative counterparts and HC. Additionally, the levels of circulating Tang cell subsets were negatively correlated with age at sampling and at diagnosis, but not disease duration or disease activity. Conclusion. Anti-dsDNA-positivity may identify a group of SLE patients with increased Tang cell subsets and circulating CD8+ Tang cells may be viewed as a potentially useful biomarker of endothelial damage and cardiovascular risk in SLE.

Highlights

Systemic lupus erythematosus (SLE) is a common autoimmune disease characterized by a dysregulation of the immune system that leads to chronic systemic inflammation [1, 2]
The endothelial damage, accelerated atherosclerosis, and increased cardiovascular disease observed in SLE patients cannot be fully explained by traditional cardiovascular risk factors or the use of corticosteroids [5]
It has been proposed that systemic inflammation, dysregulated cytokine profile, and altered T cell subsets play important roles in endothelial dysfunction and increased cardiovascular risk presenting in SLE patients [6]

Summary

Introduction

Systemic lupus erythematosus (SLE) is a common autoimmune disease characterized by a dysregulation of the immune system that leads to chronic systemic inflammation [1, 2]. SLE is associated with accelerated atherosclerosis and increased risk of cardiovascular events driving high morbidity and mortality rates [3, 4]. The endothelial damage, accelerated atherosclerosis, and increased cardiovascular disease observed in SLE patients cannot be fully explained by traditional cardiovascular risk factors or the use of corticosteroids [5]. It has been proposed that systemic inflammation, dysregulated cytokine profile, and altered T cell subsets play important roles in endothelial dysfunction and increased cardiovascular risk presenting in SLE patients [6]. A specific T cell population, termed angiogenic T cells (Tang), has been described that promotes the formation of new blood vessels and repair of damaged endothelium by cooperating with endothelial progenitor cells (EPCs) [7].

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Results

Discussion

Conclusion