Abstract
BackgroundAdipsin has been identified as a secreted adipokine that plays a critical pathogenic role in metabolic disorders. However, it is not clear regarding the association of circulating adipsin with cardiovascular disease (CVD). This study will explore the association between circulating adipsin and asymptomatic carotid atherosclerosis in Chinese obese adults.MethodsA total of 483 obese adult subjects (aged 40 years or older) were enrolled in this study. Serum adipsin concentrations and carotid intima-media thickness (CIMT) were measured to determine these associations.ResultsIndividuals with increased CIMT and asymptomatic carotid atherosclerosis had lower levels of circulating adipsin than controls (both p < 0.05). The prevalence of asymptomatic carotid atherosclerosis was significantly higher in subjects with lower levels of serum adipsin than those with higher values (42.5% vs. 36.7%, p < 0.05). Notably, subjects in the lowest quartile of serum adipsin were 1.94 times (p = 0.059) more likely to have increased CIMT and 2.91 times (p = 0.03) more likely to have asymptomatic carotid atherosclerosis than those in the highest quartile in multivariable logistic regression analyses, adjusting for age, gender, current smoking, alcohol consumption, physical activity, BMI, systolic BP, fasting glucose, total cholesterol, HDL-c, and HOMA-IR. However, such associations with circulating adipsin were not noted for atherosclerotic plaque.ConclusionsThese findings suggest that circulating adipsin concentrations are a potential marker of risks of increased CIMT and asymptomatic carotid atherosclerosis in obese Chinese adults.
Highlights
Cardiovascular disease (CVD) is the leading cause of morbidity and mortality worldwide [1], which gained worldwide attention
We aimed to explore the association between circulating adipsin and the risk of asymptomatic carotid atherosclerosis in Chinese obese adults
There are no differences in serum adipsin in subjects without atherosclerotic plaque compared to subjects with atherosclerotic plaque
Summary
Cardiovascular disease (CVD) is the leading cause of morbidity and mortality worldwide [1], which gained worldwide attention. It includes myocardial infarction, hypertension, atherosclerosis, vascular disease, and stroke [2], affecting approximately 290 million people in China [3, 4]. Subclinical CVD is a broad term that includes carotid atherosclerosis and arterial stiffness strongly associated. Adipsin has been identified as a secreted adipokine that plays a critical pathogenic role in metabolic disorders. It is not clear regarding the association of circulating adipsin with cardiovascular disease (CVD). This study will explore the association between circulating adipsin and asymptomatic carotid atherosclerosis in Chinese obese adults
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