Abstract
Adipokines refer to biologically active substances found in the adipocytes of white adipose tissue, namely, adiponectin, resistin and leptin. The circulating adipokine levels in Type 2 Diabetes mellitus and non‐Diabetes mellitus patients were determined at the Lagos University Teaching Hospital, Lagos, Nigeria. 53 diabetic and 27 non diabetic patients were recruited into the study. Fasting blood glucose (FBS), glycated haemoglobin (Hb A1C), leptin and resistin were assayed. The body mass index (BMI) was also measured. Mean diabetic BMI was not significant (P>0.05) as compared to non‐dibetics ( Diabetics 28.77+ 5.35, non‐diabetics 27.38 + 6.04. Resisitin levels were significantly higher in diabetics, 31.25 + 2.58 compared to the non‐diabetics, 16.61 + 2.16. Leptin level correlated strongly with BMI ( r = 0.620, p < 0.0001 ) and was significantly higher in the female diabetics than in males. The resistin level did not correlate with FBS and Hb A1C levels in the diabetics, while the leptin level strongly correlated with BMI in the female diabetics. Data suggest that adipokine levels may vary with gender and provides relevant information in the management of Type 2 diabetes mellitus.
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