Circulardichroismus—XXIII : Cotton-effekt einiger heterocyclisch substituierter steroidketone, deren vorstufen und des azo-chromophors

Abstract

Spiro-pyrazoline-camphor and -borneol have been prepared from camphor. In these compounds and steroids with the same heterocyclic ring the azo group is optically active (Cotton effect at 330 mμ); the rotatory strength is unusually high for the ketonees. The CD of many 20-keto steroids with other hetero rings at 16,17-position (2-pyrazolines, oxazolines and isoxazolines) has been measured and correlated with the stereochemistry of the steroid side chain. The aromatic band system of the phenyl substituted isoxazoline steroids is also highly optically active. The CD of some azetidino and diazepino steroids is discussed.