Abstract
The thalamic mechanism involved in locomotor control, particularly in steering control, was studied in a teleost, Oryzias latipes. Ipsilateral circular swimming was induced by injection of bicuculline, a selective gamma-aminobutyric acid (GABA)-A antagonist, into the unilateral posterior thalamus. δ-Amino-valeric acid, phaclofen and 2-hydroxysaclofen (weak GABA-B antagonists) had weak, but similar effects. In contrast to antagonists, injection of GABA, muscimol (GABA-A agonist), baclofen (GABA-B agonist), nipecotic acid (blocker of Na + -coupled GABA uptake carrier), and γ-hydroxybutyric acid (possible GABA-A and -B agonist) into the unilateral posterior thalamus induced contralateral circular swimming
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