Abstract
Renal cell carcinoma (RCC) is the most common malignant kidney tumor and has a high incidence rate. Circular RNAs (circRNAs) are noncoding RNAs with widespread distribution and diverse cellular functions. They are highly stable and have organ- and tissue-specific expression patterns. CircRNAs have essential functions as microRNA sponges, RNA-binding protein- and transcriptional regulators, and protein translation templates. Recent reports have shown that circRNAs are abnormally expressed in RCC and act as important regulators of RCC carcinogenesis and progression. Moreover, circRNAs have emerged as potential biomarkers for RCC diagnosis and prognosis and targets for developing new treatments. However, further studies are needed to better understand the functions of circRNAs in RCC. In this review, we summarize and discuss the recent research progress on RCC-associated circRNAs, with a focus on their potential for RCC diagnosis and targeted therapy.
Highlights
Renal cell carcinoma (RCC), the most common kidney neoplasm, originates in renal tubular epithelial cells and accounts for 85–90% of adult renal malignancies [1]
The phosphoinositide 3-kinase (PI3K)/AKT/ mammalian target of rapamycin pathway is constitutively activated in RCC and plays a crucial role
We summarize the circRNAs involved in RCC and their relevance to current clinical practice
Summary
Renal cell carcinoma (RCC), the most common kidney neoplasm, originates in renal tubular epithelial cells and accounts for 85–90% of adult renal malignancies [1]. Increasing evidence has witnessed that circRNAs play critical roles in RCC cell proliferation, apoptosis, migration, and invasion [34,35,36,37,38,39,40,41,42,43,44,45,46,47,48,49,50]. Circ-ZNF609 can work as a miR-138-5p molecular sponge, which subsequently increases levels of FOXP4, Fig. 2 Roles and regulatory pathways of RCC-related circRNAs. The schematic diagram shows the roles of circRNAs in RCC progression and the involvement of circRNAs in the miRNA-associated gene regulatory pathways the known target of miR-138-5p.
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