Abstract
BackgroundCircular RNAs are a new class of endogenous non-coding RNA that can function as crucial regulators of diverse cellular processes. The diverse types of circular RNAs with varying cytogenetics in cancer have also been reported.Main body of the abstractCircular RNAs can act as a microRNA sponge or through other mechanisms to regulate gene expression as either tumor inhibitors or accelerators, suggesting that circular RNAs can serve as newly developed biomarkers with clinic implications. Here, we summerized recent advances on circular RNAs in cancer and described a circular RNA network associated with tumorigenesis. The clinical implications of circular RNAs in cancer were also discussed in this paper.Short conclusionGrowing evidence has revealed the crucial regulatory roles of circular RNAs in cancer and the elucidation of functional mechanisms involving circular RNAs would be helpful to construct a circRNA-miRNA-mRNA regulatory network. Moreover, circular RNAs can be easily detected due to their relative stability, widespread expression, and abundance in exosomes, blood and saliva; thus, circular RNAs have potential as new and ideal clinical biomarkers in cancer.
Highlights
Circular RNAs are a new class of endogenous non-coding RNA that can function as crucial regulators of diverse cellular processes
With the improvements in novel next-generation deep sequencing and bioinformatics technology, an increasing number of circRNAs with regulatory functions were found in many tapes of cancers [4,5,6]
Differential expression profiling analysis and functional studies of circRNAs in tumors are important for the further understanding of circRNAs and cancer
Summary
Circular RNAs are a new class of endogenous non-coding RNA that can function as crucial regulators of diverse cellular processes. Differential expression profiling analysis and functional studies of circRNAs in tumors are important for the further understanding of circRNAs and cancer. Higher expression of hsa_circ_0007534 in CRC tumor tissue is associated with neoplasm staging and lymphatic metastasis [68].
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.