Circular RNA in Schizophrenia and Depression.

Wentao Zhao,Jing Li,Sha Liu,Yong Xu,Xinrong Li,Zexuan Li

doi:10.3389/fpsyt.2020.00392

Wentao Zhao, Jing Li + Show 4 more

Open Access

https://doi.org/10.3389/fpsyt.2020.00392

Copy DOI

Abstract

Schizophrenia (SZ) and depression (DEP) are two common major psychiatric disorders that are associated with high risk of suicide. These disorders affect not only physical and mental health, but they also affect the social function of the individual. However, diagnoses of SZ and DEP are mainly based on symptomatic changes and the clinical experience of psychiatrists. These rather subjective measures can induce misdiagnoses and missed diagnoses. Therefore, it is necessary to further explore objective indexes for improving the early diagnoses and prognoses of SZ and DEP. Current research indicates that non-coding RNA (ncRNA) may play a role in the occurrence and development of SZ and DEP. Circular RNA (circRNA), as an important component of ncRNA, is associated with many biological functions, especially post-transcriptional regulation. Since circRNA is easily detected in peripheral blood and has a high degree of spatiotemporal tissue specificity and stability, these attributes provide us with a new idea to further explore the potential value for the diagnosis and treatment of SZ and DEP. Here, we summarize the classification, characteristics, and biological functions of circRNA and the most significant results of experimental studies, aiming to highlight the involvement of circRNA in SZ and DEP.

Highlights

Among the great quantity molecular regulatory factors affecting gene expression, non-coding RNA is known to be a class of important regulatory factors
CircRNA in Schizophrenia and Depression the high rate of comorbidity observed in psychiatric disorders indicates a large genetic correlation between each other, and the existence of shared molecular mechanisms involved in the occurrence and development of diseases [7]
Few indepth studies have been published on specific signaling pathways and networks regulated by noncoding RNA (ncRNA) in SZ and DEP, especially in terms of circular RNAs, it is possible that further elucidation of ncRNAs may be useful for better understanding the pathogenesis of SZ and DEP

Summary

Introduction

Among the great quantity molecular regulatory factors affecting gene expression, non-coding RNA (ncRNA) is known to be a class of important regulatory factors. Efficient microRNA Sponges One of the most important molecular biological functions of circRNAs is that they indirectly affect the expression of target gene mRNAs by binding to microRNAs (miRNAs). Hsa-circRNA-103809 could be used as a sponge for miR377-3p to increase the expression of its target gene [fibroblast growth factor receptor 1 (FGFR1)] and promoted the proliferation and invasion of HCC cells.

Results

Conclusion