Abstract
Circular RNAs (circRNAs) are known to act as key regulators in a variety of malignancies. However, the role of circRNAs in cervical cancer (CCa) remains largely unknown. Herein, we demonstrated that a circRNA derived from the TADA2A gene (hsa_circ_0043280) was significantly downregulated in CCa and that this reduction in expression was correlated with a poor prognosis. Furthermore, our results demonstrated that hsa_circ_0043280 functions as a tumor suppressor to inhibit tumor growth and metastasis in CCa. Mechanistically, hsa_circ_0043280 competitively sponges miR-203a-3p and prevents miR-203a-3p from reducing the levels of PAQR3. Collectively, our results demonstrate that hsa_circ_0043280 plays a pivotal role in the development and metastasis of CCa, thus suggesting that hsa_circ_0043280 has significant potential as a prognostic biomarker and a therapeutic target for CCa.
Highlights
Cervical cancer (CCa) is the fourth most common female cancer worldwide in 2018, there were ~570,000 new cases of CCa and 311,000 deaths worldwide [1]
We identified a novel circRNA that acted as a novel tumor suppressor from a previous circRNA microarray data of CCa tissues, and verified the function of this circRNA with regards to the inhibition of tumor growth and metastasis in CCa
We demonstrated that hsa_circ_0043280, hsa_circ_0031027, and hsa_circ_0065898, were downregulated in
Summary
Cervical cancer (CCa) is the fourth most common female cancer worldwide in 2018, there were ~570,000 new cases of CCa and 311,000 deaths worldwide [1]. It is vital that we gain a better understanding of the precise mechanisms that underlie the progression and metastasis of CCa so that we can develop more specific treatment options. We identified a novel circRNA (hsa_circ_0043280) that acted as a novel tumor suppressor from a previous circRNA microarray data of CCa tissues, and verified the function of this circRNA with regards to the inhibition of tumor growth and metastasis in CCa. First, we confirmed that hsa_circ_0043280 was downregulated in CCa tissues when compared to normal cervical tissues and demonstrated that lower expression levels of hsa_circ_0043280 were correlated with a poor prognosis. We demonstrated that hsa_circ_0043280 could suppress the proliferation, migration, invasion, and metastasis of CCa cells by sponging miR-203a-3p to regulate the expression levels of progestin and adipoQ receptor 3 (PAQR3). Our results indicate that hsa_circ_0043280 exerts anticancer potential and may represent a candidate target for the treatment of CCa
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