Abstract
Room and low-temperature CD of the title dienones and trienones ( 3 to 9) clearly show that a conformational equilibrium occurs between two ring A half-chair conformers. The relative stability of the two conformers depends on substitution of ring A. These results may be extended to other series of steroids and in particular to 4-en-3-ones. CD of these enones ( 14 to 28) is consistent with a conformational equilibrium between the known quasi- cis-quasi- trans conformers. The controversial conformational behaviour of 2 β-substituted 19-nor-4-en-3-ones is explained by a dynamic equilibrium in solution between the two afore-mentioned conformers rather than by single twist or deformed boat conformer.
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