Abstract
1. It has been established that on protonation the threo isomers of phthalide-isoquinolines undergo an inversion of the signs of the CE's in the 290 and 200 nm regions, while in the case of the erythro compounds only the amplitudes of the corresponding CE's in the CD curves change. 2. An interconnection has been established between the preferred conformations of the threo and erythro forms and the relative intensities of the 'Lb CE's in the CD curves of the phthalide-isoquinolines.
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