Abstract
Circular Cryogenic Excision in Surgical Treatment of Skin Melanoma
Highlights
Melanoma is one of the most malignant and aggressive skin formations with rapid progression and poor prognosis; the disease accounts for 1.0 to 4.0% of all cancers [1, 2]
It is important that cryogenic treatment does not require anesthesia and that the surgical procedure is less complicated than traditional melanoma surgery [5, 6]
The oncocytolytic effect involves a spread of tumor antigens as a result of cryo-exposure; those antigens stimulate the production of cytotoxic T lymphocytes capable of attacking tumor cells [4, 9, 10]
Summary
Melanoma is one of the most malignant and aggressive skin formations with rapid progression and poor prognosis; the disease accounts for 1.0 to 4.0% of all cancers [1, 2]. The number of people suffering from melanoma is growing rapidly every year. In the USA, the incidence of skin melanoma increases by 4.0% annually, and in Russia this figure reaches 4.95% [3]. Back in the 1990s, it became obvious that thermoablative technologies had a number of advantages over traditional methods of surgical treatment of tumors: ablastic manipulations; reduced area of tissue removal; fewer complications, cost and time effectiveness; an extended range of indications as compared with traditional surgery [4]. It is important that cryogenic treatment does not require anesthesia and that the surgical procedure is less complicated than traditional melanoma surgery [5, 6]. The oncocytolytic effect involves a spread of tumor antigens as a result of cryo-exposure; those antigens stimulate the production of cytotoxic T lymphocytes capable of attacking tumor cells [4, 9, 10]
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