Abstract
This study investigated the effect of BMSCs transfected with CircRNA8924 on biological behaviors of Hela cells. The transfected BMSCs was then co-cultured with Hela cells and divided into CircRNA8924 mimic group, CircRNA8924 inhibitor group, and CircRNA8924 NC group followed by analysis of cell proliferation, apoptosis, migrated and invaded capacity as well as CirRNA8924 and CBX8 expression. CircRNA8924 mimic group showed highest CircRNA8924 expression followed by NC group and Inhibitor group. CircRNA8924 Inhibitor group presented significantly reduced cell proliferation and cells at S stage, decreased cell migrated and invaded capacity and elevated cell apoptotic activity (P < 0.05) compared to other two groups. In addition, significantly downregulated CircRNA8924 and CBX8 was also found in CircRNA8924 Inhibitor group (P < 0.05). In conclusion, BMSCs transfected with CircRNA8924 could down-regulate CBX8 and CircRNA8924 so as to exert regulatory action on the biological behaviors of Hela cells, indicating that CBX8 might be a therapeutic target for treating cervical cancer.
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