Abstract
Recently, many emerging circular RNAs (circRNAs) have been studied in human malignancies including cervical cancer and are involved in tumor development and oncogenesis. Here, we found that circABCB10 was higher in 58 cervical cancer tissue sample than that in the adjacent normal tissues. Higher circABCB10 expression significantly associated with advanced the International Federation of Gynecology and Obstetrics (FIGO) stage and greater lymphatic invasion, and worse survival time in cervical cancer patients. Function assays showed that circABCB10 silencing inhibited cell proliferation, migration and invasion capacities. Moreover, we demonstrated that inhibition of circABCB10 upregulated epithelial-mesenchymal transition (EMT)-related proteins E-cadherin expression and downregulated the Vimentin expression, which suggested that affected EMT signaling pathway in cervical cancer. Thus, the circABCB10 may contribute to the development of cervical cancer by affecting epithelial-mesenchymal transition signaling pathways.
Highlights
Cervical cancer (CC) is the 4th most common malignancy with about 450,000 new cases diagnosed each year (Song et al, 2019)
Practical Application: In the study, we found that circABCB10 was higher in cervical cancer tissue and high circABCB10 expression significantly associated with advanced T category and greater lymphatic invasion, and poor prognosis in patients
We found that circABCB10 was higher in cervical cancer tissue and high circABCB10 expression significantly associated with advanced T category and greater lymphatic invasion, and poor prognosis in patients
Summary
Cervical cancer (CC) is the 4th most common malignancy with about 450,000 new cases diagnosed each year (Song et al, 2019). It is urgent to explore the molecular analysis for novel therapeutic targets for cervical cancer. CircRNA8924 promotes cervical cancer cell proliferation, migration and invasion by competitively binding to miR-518d-5p /5195p family and modulating the expression of CBX8 (Liu et al, 2018). CircRNA hsa_circRNA_101996 increases cervical cancer proliferation and invasion through activating TPX2 expression by restraining miR-8075 (Song et al, 2019). Circ-ATP8A2 promotes cell proliferation and invasion as a ceRNA to target EGFR by sponging miR-433 in cervical cancer (Ding & Zhang, 2019)
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