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Abstract
Emerging evidence has uncovered critical regulatory roles of circular RNAs (circRNAs) function as dynamic scaffolding molecules in tumorigenesis and progression. However, the aberrant expression and clinical significance of hsa_circ_0058063 (circRNA_0058063) in bladder cancer (BC) remain poorly understood. circRNA expression was analyzed via a microarray in cancerous tissue and non-carcinoma tissues. Luciferase reporter assays and RNA immunoprecipitation (RIP) were both conducted to uncover the function of circRNA_0058063 in BC. circRNA_0058063 was overexpressed in BC tissues compared with adjacent normal tissues. Knockdown of circRNA_0058063 dramatically decreased cell proliferation and invasion, and promoted apoptosis in 5637 and BIU-87 cell lines. Furthermore, mechanistic investigations showed that circRNA_0058063 and FOXP4 could directly bind to miR-486-3p, demonstrating that circRNA_0058063 regulated FOXP4 expression by competitively binding to miR-486-3p. Taken together, circRNA_0058063 functions by sponging miR-486-3p in BC progression, which could act as a new biomarker and further developed to be a therapeutic target in BC.
Highlights
Bladder cancer (BC) was ranked as main factors that are responsible for the cancer-related deaths worldwide, with roughly 74,000 developed cases in the United States in 2015 (Flaig et al, 2017; Sin et al, 2017)
The aberrant expression and clinical significance of hsa_circ_0058063 in bladder cancer (BC) remain poorly understood. Circular RNA (circRNA) expression was analyzed via a microarray in cancerous tissue and non-carcinoma tissues
CircRNA_0058063 functions by sponging miR-486-3p in BC progression, which could be act as a new biomarker and further developed to be a therapeutic target in BC
Summary
Bladder cancer (BC) was ranked as main factors that are responsible for the cancer-related deaths worldwide, with roughly 74,000 developed cases in the United States in 2015 (Flaig et al, 2017; Sin et al, 2017). Numerous circRNAs have been continuously explored in various cell lines and tissue species (Xu et al, 2018). Their biological processes and potential functions are poorly understood. In lung cancer circRNA circPRKCI stimulates tumor cell growth through a ceRNA mechanism Circ-LDLRAD3 was found to be significantly associated with lymphatic/venous invasion and metastasis (Yang et al, 2017). Taken together, all these explorations potentiate circRNA’s regulatory roles as ceRNA in cancer progression
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