Abstract
Circular RNAs (circRNAs) are a group of long non-coding RNAs with enclosed structure generated by back-splicing events. Numerous members of these transcripts have been shown to affect carcinogenesis. Circular RNA itchy E3 ubiquitin protein ligase (circITCH) is a circRNA created from back splicing events in ITCH gene, a protein coding gene on 20q11.22 region. ITCH has a role as a catalyzer for ubiquitination through both proteolytic and non-proteolytic routes. CircITCH is involved in the pathetiology of cancers through regulation of the linear isoform as well as serving as sponge for several microRNAs, namely miR-17, miR-224, miR-214, miR-93-5p, miR-22, miR-7, miR-106a, miR-10a, miR-145, miR-421, miR-224-5p, miR-197 and miR-199a-5p. CircITCH is also involved in the modulation of Wnt/β-catenin and PTEN/PI3K/AKT pathways. Except from a single study in osteosarcoma, circITCH has been found to exert tumor suppressor role in diverse cancers. In the present manuscript, we provided a comprehensive review of investigations that reported function of circITCH in the carcinogenesis.
Highlights
Circular RNAs are a group of long non-coding RNAs with enclosed structure
We provided a comprehensive review of investigations that reported function of circITCH in this process
Except from a single study in osteosarcoma, circITCH has been found to exert tumor suppressor role in diverse cancers. This circRNA is involved in the pathetiology of cancers through regulation of the linear isoform as well as serving as sponge for several microRNAs, namely miR-17, miR-224, miR-214, miR-935p, miR-22, miR-7, miR-106a, miR-10a, miR-145, miR-421, miR224-5p, miR-197 and miR-199a-5p
Summary
Circular RNAs (circRNAs) are a group of long non-coding RNAs with enclosed structure. CircRNAs have been shown to affect different cellular and biological processes, namely cell proliferation [1], differentiation, pluripotency [2] and epithelial-mesenchymal transition (EMT) [3]. Different mechanisms have been suggested for circRNAs effects in these processes with the most appreciated one being their function as decoys for microRNAs (miRNAs) or RNA-binding proteins. Circular RNA itchy E3 ubiquitin protein ligase (circITCH) is an example of cancer-related circRNAs which can be used as target for therapeutic interventions. It is created from back splicing events in ITCH gene, a protein coding gene on 20q11.22 region. The evidence regarding the role of circITCH in cancers is classified based on the samples/models used in the original papers to in vitro, in vivo and clinical studies
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