Circadien cycle and chronic central serous chorioretinopathy

Abstract

AbstractPurpose Chronic central serous chorioretinopathy (CSCR) is a multifactorial disease. The present study was designed to evaluate the prevalence of circadian disturbance and corticosteroid treatment in patients treated with chronic CSCR.Methods Patients presenting with chronic CSCR between 01/01/2009 and 30/11/2011 were prospectively enrolled. A history of corticosteroid treatment, sleep disturbances and irregular working hours was noted. Two questionnaires (PSQI and Epworth) regarding sleeping distrurbancies were applied. After a follow up of 3 months, the patients with persisting fluid and visual acuity below 20/40 were treated with photodynamic therapy (PDT).Results During the period of inclusion, among 26 included patients, 19 were treated with PDT (73%). A history of corticosteroid tretment was found in 12 patients (19%), 4 currently used psychopharmacologic drugs (15%) and 8 had irregular working hours (30%). The analysis of the Epworth questionnaire enabled to record moderate sleeping disturbances in 11 patients (42%), none of the patients were classified as having severe sleeping disturbances.Conclusion It is likely that general factors such as the existence of a corticosteroid treatment or a disruption of the circadian cycle are involved in the occurrence of patients with CSCR.