Abstract
Cortisol concentrations in the cerebrospinal fluid (CSF) of the rhesus monkey were found to undergo a marked diurnal variation. Hourly samples of CSF from 4 adult male rhesus monkeys showed a mean peak cortisol concentration of 1.56 ± .29 μg% occuring between 0800–0900 hrs and a mean minimum concentration between 2200-0000 hrs of 0.21 ± .06 μg%. The mean daily CSF cortisol concentration increase was 900%, a greater variation than has been reported for plasma cortisol diurnal changes.
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