Abstract
Abstract Vitamin B12 (VB12) is known as a putative modulator for the mammalian circadian clock. In an attempt to analyze the mechanism by which VB12 modulates the clock system, circadian time (CT) dependency of two VB12 analogs, methylcobalamin (methyl‐B12) and cyanocobalamin (cyano‐B12), was investigated by means of recording sleep‐wake and brain temperature (Tbr) rhythms over 3 weeks in rats freerunning under continuous dim illumination (dim LL). A 3‐h intracerebroventricular infusion of methyl‐B12 (30 nmol) was‐done at three different CT phases such as CT 12–15 (starting at activity onset), CT 18–21 (starting mid at active period) and CT 0–3 (starting at activity offset). A significant enhancement of both non‐rapid‐eye‐movement sleep and rapid‐eye‐movement sleep in phase with a significant reduction of Tbr was acutely induced during the late subjective night by the administration of methyl‐B12 at CT 12–15 and at CT 18–21. In contrast, sleep and Tbr were little affected by the infusion at CT 0–3. Subseq...
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