Abstract
Twenty-four hour patterns in somatostatin (SS)-like immunoreactivity (LI) within the suprachiasmatic nucleus (SCN) were determined by enzyme immunoassay in rats blinded by bilateral orbital enucleation or kept sighted under light-dark conditions. A remarkable circadian rhythm was found in the concentration of SS-LI in the SCN under blinded conditions. The peak time appeared at about circadian time (CT) 4 in the early subjective day and the trough at around CT 16 or 20 in the subjective night. Light-dark cycles did not alter the circadian patterns of SS-LI observed in the blinded rat SCN. These results indicate the presence of an endogenous circadian rhythm in SS-LI in the rat SCN, independent of environmental lighting cycles.
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