Abstract
The aim of this experiment is to study the circadian rhythm of oxidant-antioxidant components in the body. A total of 20 adult male rabbits were divided into 2 groups (G1and G2)and kept in 2 different rooms. Serum was isolated after blood collection at 12 A.M or 12 P.M respectively from G1 and G2.The results reveal a significant elevation in serum GSH, MDA and SOD during night hours. The B-endorphin showed a value of 84.36±1.36 in rabbits serum during night compared with 53.23±1.12 during day hours. Serum ACTH and cortisone concentration during night hours expressed a value of 71.03±0.16 and 24.46±0.38 compared to 52.80±0.37 and 11.80±0.57 during day hours respectively. Protein carbonyl contents shows a regular variation between serum and tissues during day and night hours. It was concluded that the oxidant-antioxidant imbalance lead to such variation between day and night hours due to activities and metabolism. Extensive research is needed to minimize and overlap such stress.
Highlights
ومحتوى البروتين الكربوني في المصل وأنسجة الدماغ و الغدة الكظريةHPA الايقاع اليومي لعوامل الأكسدة ومضاداتها ومحور
The circadian rhythms of reactive oxygen species and antioxidants have been of great concern because of their critical role variations of oxidant-antioxidant markers and the hypothalamic–pituitary–adrenal axis (HPA axis) during day and night hours
In the development of many diseases, including malignant tumors [1].Disruption of the circadian cycle is closely correlated with metabolic imbalance, as seen by working night individuals or rotating shifts [2].the aim of this research is the knowledge of a systematic study of circadian variations of oxidant-antioxidant components in serum and some tissues in the body
Summary
ومحتوى البروتين الكربوني في المصل وأنسجة الدماغ و الغدة الكظريةHPA الايقاع اليومي لعوامل الأكسدة ومضاداتها ومحور. The circadian rhythms of reactive oxygen species and antioxidants have been of great concern because of their critical role variations of oxidant-antioxidant markers and the hypothalamic–pituitary–adrenal axis (HPA axis) during day and night hours. Little is known about the role of oxidantantioxidant agents during day and night hours. Protein carbonyl content (PCC), which is the most frequently used marker of oxidative protein modification [5].While ACTH activates the adrenal gland to initiate a peripheral stress response, β-endorphin attenuates the stress response, at least in part, by inhibiting CRH secretion [6]. Beta-endorphin is a morphine-like active ingredient secreted by the pituitary and hypothalamic glands [7].,the
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