Circadian rhythms and patterns of running-wheel activity, feeding and drinking behaviors of old male rats

Abstract

Running-wheel activity of 7 young adult male rats (3 to 6.5 months of age) and 11 old male rats (22 to 34 months of age), feeding behavior of 10 each of young adult and old male rats and drinking behavior of 6 each of young adult and old male rats were recorded. Circadian rhythms were lost in 2, 6 and 1 old rats respectively in running activity, feeding and drinking behaviors. Loss of circadian rhythm of three behaviors seems not to occur concomitantly. Although the remaining old rats still showed as high a percentage of nocturnal activities in these three behaviors as young rats, the patterns of the behaviors revealed age-related changes. Old rats had decreased daily activity with small numbers and short duration of bursts of activity. Total frequencies of the head of rats interrupting the photobeam of a feeder during 24 hour period increased in old age with patterns of a small number of long meals with a rapid ingestion rate. Total numbers of licking the spout per day increased in old rats with patterns of a small number of short duration draft with a rapid licking rate. Old rats still maintained diurnal difference of drinking-to-feeding ratio. The similarity of the feeding and drinking patterns between old male rats and ventromedial hypothalamus lesioned rats was discussed.