Abstract
Adult rats fed ad libitum and on restricted-feeding (food available between 10:00 and 16:00) regimen showed feeding-cued circadian rhythms in the activity patterns of glycyld-L-leucine and L-leucine absorption by the proximal small intestine. Absorption of the two compounds by the distal small intestine followed these similar, but less overt, rhythmic patterns. The glycyl-L-leucine hydrolase activity of cytosolic fraction of the mucosal homogenates from the proximal intestine also exhibited a similar daily rhythm in the rats on restricted-feeding regimen, but no discernible rhythm in the rats fed ad libitum. Rhythmicity of the hydrolase activity was hardly noticeable in the membrane fraction on either feeding regimen. Restricted-feeding resulted in an enhanced daily average level for those intestinal activities. In the presence of bestatin, rhythmicity of glycyl-L-leucine absorption by the proximal intestine was unimpaired while cytosolic and membrane hydrolysis of the dipeptide was severely inhibited. Th...
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